What Moves Like SPRO

Spero Therapeutics, Inc. Pharmaceutical Preparations · Nasdaq

The tradable tickers whose daily moves track SPRO most closely over the past year, filtered to risk comparable with SPRO's own.

Closest match

RXRX Recursion Pharmaceuticals, Inc. — 0.369 correlation over the past year, and 19% choppier than SPRO.

251 sessions to 2026-09-10 · SPRO volatility 60.7% annualised · $1.6M a day
Ticker 1-year correlation 3-year Volatility vs SPRO Risk What it is
RXRX Recursion Pharmaceuticals, Inc.
0.369
0.176 1.19× 19% choppier Biological Products, (No Diagnostic Substances)
IBM International Business Machines Corporation
0.341
0.142 0.80× 20% calmer Computer & Office Equipment
ERIC Ericsson
0.328
0.162 0.65× 35% calmer Radio & TV Broadcasting & Communications Equipment
CRBU Caribou Biosciences, Inc.
0.328
0.156 1.22× 22% choppier Biological Products, (No Diagnostic Substances)
VYGR Voyager Therapeutics, Inc.
0.321
0.152 0.98× similar Biological Products, (No Diagnostic Substances)
PRTA Prothena Corporation plc
0.319
0.162 0.79× 21% calmer Pharmaceutical Preparations
MGNX MacroGenics, Inc.
0.316
0.095 1.42× 42% choppier Pharmaceutical Preparations
AFRM Affirm Holdings, Inc.
0.316
0.124 0.99× similar Personal Credit Institutions
ARKG ARK Genomic Revolution ETF
0.313
0.216 0.74× 26% calmer Fund
EGAN eGain Corporation
0.312
0.114 1.06× similar Services-Prepackaged Software
ARKK ARK Innovation ETF
0.310
0.199 0.63× 38% calmer Fund
UPST Upstart Holdings, Inc.
0.310
0.132 1.08× similar Finance Services
DMRC Digimarc Corporation
0.306
0.190 1.46× 46% choppier Services-Computer Integrated Systems Design
CPRI Capri Holdings Limited Ordinary Shares
0.305
0.086 0.76× 24% calmer Leather & Leather Products
FDIG Fidelity Crypto Industry and Digital Payments ETF
0.305
0.145 0.84× 16% calmer Fund
ENPH Enphase Energy, Inc.
0.303
0.138 1.36× 36% choppier Semiconductors & Related Devices
FENC Fennec Pharmaceuticals Inc.
0.301
0.156 1.10× 10% choppier Biological Products, (No Diagnostic Substances)

Showing 17 of 17 tickers that qualified. Correlation is of daily returns; 1.000 would mean moving in lockstep, 0.000 no relationship at all.

What this is for

Three questions, one number behind all of them.

How to read the two correlation columns

The one-year figure is what the relationship looks like now. The three-year figure is what it has looked like over a longer stretch. Comparing them is the point: when they agree, the relationship is structural and likely to hold. When the one-year number is far below the three-year one, something has changed — a shift in business mix, an index reconstitution, a sector that has stopped moving together — and the recent figure is the one to trust less, not more.

Correlation measures whether two things move together, not whether they move by the same amount. That is why the volatility column is there. Two tickers can correlate at 0.99 while one swings half again as hard, and swapping one for the other would quietly change how much risk you are carrying.

What was deliberately left out

Ranking purely by correlation produces answers that are mathematically perfect and practically useless. The closest matches to AAPL by raw correlation are leveraged AAPL funds at 0.999 — correct, and not replacements for anything. Four filters run before a ticker is allowed to appear:

Where all of that leaves a ticker with no close match, the page says so. A stock with no substitute is a real and useful finding, and inventing a loose one to fill the table would be worse than an empty answer.

Limits, stated up front

Where the numbers come from

Correlations are computed in-house from a daily price history and rebuilt every night. What gets published is the derived statistic — a correlation coefficient, a volatility ratio, an observation count — and nothing from which a price or return series could be reconstructed. The rest of the Markets section is on the Markets overview, including futures positioning extremes and SEC Form 4 insider transactions.