What Moves Like PRTA

Prothena Corporation plc Pharmaceutical Preparations · Nasdaq

The tradable tickers whose daily moves track PRTA most closely over the past year, filtered to risk comparable with PRTA's own.

Closest match

XBI State Street SPDR S&P Biotech ETF — 0.556 correlation over the past year, and 38% calmer than PRTA.

About PRTA

Annualised volatility 48.9%
Beta vs SPY 1.09
Market correlation 0.304
Traded per day $4.2M
Rate sensitivity -0.24
Volatility sensitivity -0.34

As filed with the SEC twelve months to 2025-12-31 · balance sheet 2026-03-31

Revenue $9.7M
Operating income -$214.6M
Net income -$244.1M
Diluted EPS $-4.53
Total assets $349.9M
Total liabilities $37.3M
Shareholders' equity $312.6M
Cash & equivalents $329.5M
Shares outstanding 53.1M
251 sessions to 2026-11-09 · PRTA volatility 48.9% annualised · $4.2M a day
Ticker 1-year correlation 3-year Volatility vs PRTA Risk What it is
XBI State Street SPDR S&P Biotech ETF
0.556
0.496 0.62× 38% calmer Fund
SBIO ALPS Medical Breakthroughs ETF
0.525
0.491 0.69× 31% calmer Fund
IDNA iShares Genomics Immunology and Healthcare ETF
0.493
0.445 0.64× 36% calmer Fund
MGTX MeiraGTx Holdings plc
0.466
0.358 1.20× 20% choppier Biological Products, (No Diagnostic Substances)
NTLA Intellia Therapeutics, Inc.
0.460
0.325 1.56× 56% choppier In Vitro & In Vivo Diagnostic Substances
GNOM Global X Genomics & Biotechnology ETF
0.448
0.437 0.72× 28% calmer Fund
VIR Vir Biotechnology, Inc.
0.446
0.305 1.35× 35% choppier Biological Products, (No Diagnostic Substances)
VYGR Voyager Therapeutics, Inc.
0.439
0.355 1.26× 26% choppier Biological Products, (No Diagnostic Substances)
CRSP CRISPR Therapeutics AG
0.436
0.336 1.19× 19% choppier Biological Products, (No Diagnostic Substances)
LXEO Lexeo Therapeutics, Inc.
0.433
0.259 1.46× 46% choppier Biological Products, (No Diagnostic Substances)
ARVN Arvinas, Inc.
0.432
0.294 1.16× 16% choppier Pharmaceutical Preparations
BNTC Benitec Biopharma Inc.
0.431
0.156 1.18× 18% choppier Pharmaceutical Preparations
DNLI Denali Therapeutics Inc.
0.428
0.438 1.13× 13% choppier Biological Products, (No Diagnostic Substances)
SLDB Solid Biosciences Inc.
0.424
0.296 1.57× 57% choppier Biological Products, (No Diagnostic Substances)
KROS Keros Therapeutics, Inc.
0.421
0.221 1.04× similar Pharmaceutical Preparations
PROK ProKidney Corp. - Class A Ordinary Shares
0.421
0.235 1.52× 52% choppier Biological Products, (No Diagnostic Substances)
RCKT Rocket Pharmaceuticals, Inc.
0.418
0.420 1.40× 40% choppier Pharmaceutical Preparations
ARKG ARK Genomic Revolution ETF
0.416
0.395 0.97× similar Fund
RXRX Recursion Pharmaceuticals, Inc.
0.411
0.355 1.52× 52% choppier Biological Products, (No Diagnostic Substances)
RCUS Arcus Biosciences, Inc.
0.408
0.324 1.28× 28% choppier Pharmaceutical Preparations
ASMB Assembly Biosciences, Inc.
0.407
0.250 1.21× 21% choppier Pharmaceutical Preparations
DCTH Delcath Systems, Inc.
0.406
0.148 1.24× 24% choppier Surgical & Medical Instruments & Apparatus
SRPT Sarepta Therapeutics, Inc.
0.405
0.245 1.45× 45% choppier Pharmaceutical Preparations
ENTA Enanta Pharmaceuticals, Inc.
0.403
0.233 1.01× similar Pharmaceutical Preparations
SANA Sana Biotechnology, Inc.
0.402
0.284 1.55× 55% choppier Biological Products, (No Diagnostic Substances)

Showing 25 of 30 tickers that qualified. Correlation is of daily returns; 1.000 would mean moving in lockstep, 0.000 no relationship at all.

What this is for

Three questions, one number behind all of them.

How to read the two correlation columns

The one-year figure is what the relationship looks like now. The three-year figure is what it has looked like over a longer stretch. Comparing them is the point: when they agree, the relationship is structural and likely to hold. When the one-year number is far below the three-year one, something has changed — a shift in business mix, an index reconstitution, a sector that has stopped moving together — and the recent figure is the one to trust less, not more.

Correlation measures whether two things move together, not whether they move by the same amount. That is why the volatility column is there. Two tickers can correlate at 0.99 while one swings half again as hard, and swapping one for the other would quietly change how much risk you are carrying.

What was deliberately left out

Ranking purely by correlation produces answers that are mathematically perfect and practically useless. The closest matches to AAPL by raw correlation are leveraged AAPL funds at 0.999 — correct, and not replacements for anything. Four filters run before a ticker is allowed to appear:

Where all of that leaves a ticker with no close match, the page says so. A stock with no substitute is a real and useful finding, and inventing a loose one to fill the table would be worse than an empty answer.

Limits, stated up front

Where the numbers come from

Correlations are computed in-house from a daily price history and rebuilt every night. What gets published is the derived statistic — a correlation coefficient, a volatility ratio, an observation count — and nothing from which a price or return series could be reconstructed. The rest of the Markets section is on the Markets overview, including futures positioning extremes and SEC Form 4 insider transactions.