What Moves Like VRTX

Vertex Pharmaceuticals Incorporated Pharmaceutical Preparations · Nasdaq

The tradable tickers whose daily moves track VRTX most closely over the past year, filtered to risk comparable with VRTX's own.

Closest match

IBB iShares Biotechnology ETF — 0.676 correlation over the past year, and 24% calmer than VRTX.

About VRTX

Annualised volatility 28.7%
Beta vs SPY 0.51
Market correlation 0.230
Traded per day $609.6M
Rate sensitivity -0.30
Volatility sensitivity -0.29

As filed with the SEC twelve months to 2025-12-31 · balance sheet 2026-03-31

Revenue $12.00B
Operating income $4.17B
Net income $3.95B
Diluted EPS $15.32
Total assets $26.48B
Total liabilities $7.12B
Shareholders' equity $19.36B
Cash & equivalents $5.49B
Shares outstanding 254.2M
252 sessions to 2026-09-30 · VRTX volatility 28.7% annualised · $609.6M a day
Ticker 1-year correlation 3-year Volatility vs VRTX Risk What it is
IBB iShares Biotechnology ETF
0.676
0.566 0.76× 24% calmer Fund
FBT First Trust Amex Biotech Index Fund
0.608
0.496 0.76× 25% calmer Fund
PJP Invesco Pharmaceuticals ETF
0.605
0.460 0.60× 40% calmer Fund
PPH VanEck Pharmaceutical ETF
0.584
0.452 0.64× 36% calmer Fund
IHE iShares U.S. Pharmaceutical ETF
0.572
0.448 0.63× 37% calmer Fund
PINK Simplify Health Care ETF
0.552
0.460 0.64× 36% calmer Fund
AMGN Amgen Inc.
0.535
0.394 1.03× similar Biological Products, (No Diagnostic Substances)
XBI State Street SPDR S&P Biotech ETF
0.496
0.423 0.98× similar Fund
HQH abrdn Healthcare Investors Shares of Beneficial Interest
0.492
0.447 0.75× 26% calmer —
THQ abrdn Healthcare Opportunities Fund Shares of Beneficial Interest
0.491
0.421 0.64× 36% calmer —
ABBV AbbVie Inc.
0.484
0.361 0.91× similar Pharmaceutical Preparations
HQL abrdn Life Sciences Investors Shares of Beneficial Interest
0.471
0.460 0.80× 20% calmer —
GILD Gilead Sciences, Inc.
0.470
0.339 0.92× similar Biological Products, (No Diagnostic Substances)
NVS Novartis AG
0.467
0.347 0.92× similar Pharmaceutical Preparations
BIIB Biogen Inc.
0.467
0.351 1.22× 22% choppier Biological Products, (No Diagnostic Substances)
LLY Eli Lilly and Company
0.459
0.329 1.23× 23% choppier Pharmaceutical Preparations
THW abrdn World Healthcare Fund Shares of Beneficial Interest
0.458
0.366 0.69× 31% calmer —
BMY Bristol-Myers Squibb Company
0.448
0.273 0.96× similar Pharmaceutical Preparations
RPRX Royalty Pharma plc - Class A Ordinary Shares
0.442
0.255 0.80× 20% calmer Pharmaceutical Preparations
AZN AstraZeneca PLC Ordinary Shares
0.427
0.303 0.99× similar Pharmaceutical Preparations
PFE Pfizer, Inc.
0.421
0.197 0.77× 23% calmer Pharmaceutical Preparations
INCY Incyte Corporation
0.415
0.327 1.16× 16% choppier Services-Commercial Physical & Biological Research
XPH State Street SPDR S&P Pharmaceuticals ETF
0.415
0.366 0.81× 19% calmer Fund
BMRN BioMarin Pharmaceutical Inc.
0.411
0.269 1.22× 22% choppier Pharmaceutical Preparations
REGN Regeneron Pharmaceuticals, Inc.
0.410
0.358 1.17× 17% choppier Pharmaceutical Preparations

Showing 25 of 30 tickers that qualified. Correlation is of daily returns; 1.000 would mean moving in lockstep, 0.000 no relationship at all.

What this is for

Three questions, one number behind all of them.

How to read the two correlation columns

The one-year figure is what the relationship looks like now. The three-year figure is what it has looked like over a longer stretch. Comparing them is the point: when they agree, the relationship is structural and likely to hold. When the one-year number is far below the three-year one, something has changed — a shift in business mix, an index reconstitution, a sector that has stopped moving together — and the recent figure is the one to trust less, not more.

Correlation measures whether two things move together, not whether they move by the same amount. That is why the volatility column is there. Two tickers can correlate at 0.99 while one swings half again as hard, and swapping one for the other would quietly change how much risk you are carrying.

What was deliberately left out

Ranking purely by correlation produces answers that are mathematically perfect and practically useless. The closest matches to AAPL by raw correlation are leveraged AAPL funds at 0.999 — correct, and not replacements for anything. Four filters run before a ticker is allowed to appear:

Where all of that leaves a ticker with no close match, the page says so. A stock with no substitute is a real and useful finding, and inventing a loose one to fill the table would be worse than an empty answer.

Limits, stated up front

Where the numbers come from

Correlations are computed in-house from a daily price history and rebuilt every night. What gets published is the derived statistic — a correlation coefficient, a volatility ratio, an observation count — and nothing from which a price or return series could be reconstructed. The rest of the Markets section is on the Markets overview, including futures positioning extremes and SEC Form 4 insider transactions.