What Moves Like KRYS

Krystal Biotech, Inc. Biological Products, (No Diagnostic Substances) · Nasdaq

The tradable tickers whose daily moves track KRYS most closely over the past year, filtered to risk comparable with KRYS's own.

Closest match

XBI State Street SPDR S&P Biotech ETF — 0.498 correlation over the past year, and 28% calmer than KRYS.

About KRYS

Annualised volatility 39.0%
Beta vs SPY 0.84
Market correlation 0.276
Traded per day $94.4M

As filed with the SEC twelve months to 2025-12-31 · balance sheet 2026-03-31

Revenue $389.1M
Operating income $161.3M
Net income $204.8M
Diluted EPS $6.84
Total assets $1.40B
Total liabilities $120.2M
Shareholders' equity $1.28B
Cash & equivalents $501.3M
Shares outstanding 29.4M
252 sessions to 2026-09-10 · KRYS volatility 39.0% annualised · $94.4M a day
Ticker 1-year correlation 3-year Volatility vs KRYS Risk What it is
XBI State Street SPDR S&P Biotech ETF
0.498
0.566 0.72× 28% calmer Fund
SBIO ALPS Medical Breakthroughs ETF
0.442
0.535 0.80× 20% calmer Fund
ACAD ACADIA Pharmaceuticals Inc.
0.427
0.290 0.97× similar Pharmaceutical Preparations
ARKG ARK Genomic Revolution ETF
0.421
0.460 1.15× 15% choppier Fund
DNLI Denali Therapeutics Inc.
0.368
0.389 1.45× 45% choppier Biological Products, (No Diagnostic Substances)
ARKK ARK Innovation ETF
0.365
0.370 0.97× similar Fund
PTCT PTC Therapeutics, Inc.
0.364
0.293 1.03× similar Pharmaceutical Preparations
CGON CG Oncology, Inc.
0.362
1.45× 45% choppier Biological Products, (No Diagnostic Substances)
CRSP CRISPR Therapeutics AG
0.355
0.349 1.54× 54% choppier Biological Products, (No Diagnostic Substances)
TGTX TG Therapeutics, Inc.
0.351
0.306 1.17× 17% choppier Pharmaceutical Preparations
MIRM Mirum Pharmaceuticals, Inc.
0.344
0.317 1.17× 17% choppier Pharmaceutical Preparations
AVBP ArriVent BioPharma, Inc.
0.342
1.49× 49% choppier Pharmaceutical Preparations
SDGR Schrodinger, Inc.
0.335
0.324 1.40× 40% choppier Pharmaceutical Preparations
KROS Keros Therapeutics, Inc.
0.334
0.270 1.28× 28% choppier Pharmaceutical Preparations
IWC iShares Microcap ETF
0.331
0.401 0.61× 39% calmer Fund
NTRA Natera, Inc.
0.319
0.283 1.23× 23% choppier Services-Medical Laboratories
RYTM Rhythm Pharmaceuticals, Inc.
0.319
0.283 1.19× 19% choppier Pharmaceutical Preparations
DWAS Invesco Dorsey Wright SmallCap Momentum ETF
0.318
0.377 0.67× 33% calmer Fund
SRRK Scholar Rock Holding Corporation
0.308
0.249 1.55× 55% choppier Biological Products, (No Diagnostic Substances)
VRTX Vertex Pharmaceuticals Incorporated
0.308
0.263 0.74× 26% calmer Pharmaceutical Preparations
MGTX MeiraGTx Holdings plc
0.307
0.324 1.54× 54% choppier Biological Products, (No Diagnostic Substances)
DNTH Dianthus Therapeutics, Inc.
0.306
0.233 1.57× 57% choppier Pharmaceutical Preparations
CLDX Celldex Therapeutics, Inc.
0.306
0.433 1.30× 30% choppier In Vitro & In Vivo Diagnostic Substances
NAMS NewAmsterdam Pharma Company N.V.
0.305
0.164 1.46× 46% choppier Pharmaceutical Preparations
ARKF ARK Blockchain & Fintech Innovation ETF
0.304
0.297 0.88× 12% calmer Fund

Showing 25 of 27 tickers that qualified. Correlation is of daily returns; 1.000 would mean moving in lockstep, 0.000 no relationship at all.

What this is for

Three questions, one number behind all of them.

How to read the two correlation columns

The one-year figure is what the relationship looks like now. The three-year figure is what it has looked like over a longer stretch. Comparing them is the point: when they agree, the relationship is structural and likely to hold. When the one-year number is far below the three-year one, something has changed — a shift in business mix, an index reconstitution, a sector that has stopped moving together — and the recent figure is the one to trust less, not more.

Correlation measures whether two things move together, not whether they move by the same amount. That is why the volatility column is there. Two tickers can correlate at 0.99 while one swings half again as hard, and swapping one for the other would quietly change how much risk you are carrying.

What was deliberately left out

Ranking purely by correlation produces answers that are mathematically perfect and practically useless. The closest matches to AAPL by raw correlation are leveraged AAPL funds at 0.999 — correct, and not replacements for anything. Four filters run before a ticker is allowed to appear:

Where all of that leaves a ticker with no close match, the page says so. A stock with no substitute is a real and useful finding, and inventing a loose one to fill the table would be worse than an empty answer.

Limits, stated up front

Where the numbers come from

Correlations are computed in-house from a daily price history and rebuilt every night. What gets published is the derived statistic — a correlation coefficient, a volatility ratio, an observation count — and nothing from which a price or return series could be reconstructed. The rest of the Markets section is on the Markets overview, including futures positioning extremes and SEC Form 4 insider transactions.