What Moves Like PTGX

Protagonist Therapeutics, Inc. Pharmaceutical Preparations · Nasdaq

The tradable tickers whose daily moves track PTGX most closely over the past year, filtered to risk comparable with PTGX's own.

Closest match

SBIO ALPS Medical Breakthroughs ETF — 0.454 correlation over the past year, and 38% calmer than PTGX.

About PTGX

Annualised volatility 50.6%
Beta vs SPY 0.18
Market correlation 0.044
Traded per day $67.2M
Rate sensitivity -0.26
Volatility sensitivity -0.07

As filed with the SEC twelve months to 2025-12-31 · balance sheet 2026-03-31

Operating income -$158.1M
Net income -$130.1M
Diluted EPS $-2.05
Total assets $697.5M
Total liabilities $42.0M
Shareholders' equity $655.5M
Cash & equivalents $193.7M
Shares outstanding 64.2M
252 sessions to 2026-09-10 · PTGX volatility 50.6% annualised · $67.2M a day
Ticker 1-year correlation 3-year Volatility vs PTGX Risk What it is
SBIO ALPS Medical Breakthroughs ETF
0.454
0.445 0.62× 38% calmer Fund
PCVX Vaxcyte, Inc.
0.435
0.267 0.91× similar Biological Products, (No Diagnostic Substances)
NAMS NewAmsterdam Pharma Company N.V.
0.421
0.204 1.12× 12% choppier Pharmaceutical Preparations
PTCT PTC Therapeutics, Inc.
0.342
0.240 0.80× 20% calmer Pharmaceutical Preparations
ZYME Zymeworks Inc.
0.335
0.273 1.07× similar Pharmaceutical Preparations
SRRK Scholar Rock Holding Corporation
0.333
0.231 1.19× 19% choppier Biological Products, (No Diagnostic Substances)
TRVI Trevi Therapeutics, Inc.
0.321
0.336 1.18× 18% choppier Pharmaceutical Preparations
ODC Oil-Dri Corporation Of America
0.319
0.168 0.76× 24% calmer Miscellaneous Manufacturing Industries
LXEO Lexeo Therapeutics, Inc.
0.317
1.52× 52% choppier Biological Products, (No Diagnostic Substances)
DNTH Dianthus Therapeutics, Inc.
0.314
0.233 1.21× 21% choppier Pharmaceutical Preparations
XNCR Xencor, Inc.
0.313
0.293 1.33× 33% choppier Pharmaceutical Preparations
TARS Tarsus Pharmaceuticals, Inc.
0.300
0.211 0.92× similar Biological Products, (No Diagnostic Substances)

Showing 12 of 12 tickers that qualified. Correlation is of daily returns; 1.000 would mean moving in lockstep, 0.000 no relationship at all.

What this is for

Three questions, one number behind all of them.

How to read the two correlation columns

The one-year figure is what the relationship looks like now. The three-year figure is what it has looked like over a longer stretch. Comparing them is the point: when they agree, the relationship is structural and likely to hold. When the one-year number is far below the three-year one, something has changed — a shift in business mix, an index reconstitution, a sector that has stopped moving together — and the recent figure is the one to trust less, not more.

Correlation measures whether two things move together, not whether they move by the same amount. That is why the volatility column is there. Two tickers can correlate at 0.99 while one swings half again as hard, and swapping one for the other would quietly change how much risk you are carrying.

What was deliberately left out

Ranking purely by correlation produces answers that are mathematically perfect and practically useless. The closest matches to AAPL by raw correlation are leveraged AAPL funds at 0.999 — correct, and not replacements for anything. Four filters run before a ticker is allowed to appear:

Where all of that leaves a ticker with no close match, the page says so. A stock with no substitute is a real and useful finding, and inventing a loose one to fill the table would be worse than an empty answer.

Limits, stated up front

Where the numbers come from

Correlations are computed in-house from a daily price history and rebuilt every night. What gets published is the derived statistic — a correlation coefficient, a volatility ratio, an observation count — and nothing from which a price or return series could be reconstructed. The rest of the Markets section is on the Markets overview, including futures positioning extremes and SEC Form 4 insider transactions.