What Moves Like PCVX

Vaxcyte, Inc. Biological Products, (No Diagnostic Substances) · Nasdaq

The tradable tickers whose daily moves track PCVX most closely over the past year, filtered to risk comparable with PCVX's own.

Closest match

XBI State Street SPDR S&P Biotech ETF — 0.659 correlation over the past year, and 39% calmer than PCVX.

About PCVX

Annualised volatility 45.9%
Beta vs SPY 0.91
Market correlation 0.254
Traded per day $65.1M

As filed with the SEC twelve months to 2025-12-31 · balance sheet 2026-03-31

Operating income -$923.7M
Net income -$766.6M
Diluted EPS $-5.63
Total assets $3.35B
Total liabilities $352.3M
Shareholders' equity $3.00B
Cash & equivalents $260.8M
Shares outstanding 144.3M
252 sessions to 2026-09-10 · PCVX volatility 45.9% annualised · $65.1M a day
Ticker 1-year correlation 3-year Volatility vs PCVX Risk What it is
XBI State Street SPDR S&P Biotech ETF
0.659
0.536 0.61× 39% calmer Fund
SBIO ALPS Medical Breakthroughs ETF
0.644
0.532 0.68× 32% calmer Fund
DNLI Denali Therapeutics Inc.
0.481
0.426 1.23× 23% choppier Biological Products, (No Diagnostic Substances)
BCYC Bicycle Therapeutics plc
0.479
0.307 1.12× 12% choppier Pharmaceutical Preparations
SRRK Scholar Rock Holding Corporation
0.478
0.239 1.31× 31% choppier Biological Products, (No Diagnostic Substances)
VIR Vir Biotechnology, Inc.
0.469
0.266 1.42× 42% choppier Biological Products, (No Diagnostic Substances)
VKTX Viking Therapeutics, Inc.
0.469
0.241 1.30× 30% choppier Pharmaceutical Preparations
CLDX Celldex Therapeutics, Inc.
0.450
0.349 1.10× similar In Vitro & In Vivo Diagnostic Substances
MIRM Mirum Pharmaceuticals, Inc.
0.449
0.267 0.99× similar Pharmaceutical Preparations
KURA Kura Oncology, Inc.
0.442
0.294 1.32× 32% choppier Pharmaceutical Preparations
PTGX Protagonist Therapeutics, Inc.
0.435
0.267 1.10× 10% choppier Pharmaceutical Preparations
PTCT PTC Therapeutics, Inc.
0.430
0.263 0.88× 12% calmer Pharmaceutical Preparations
MGTX MeiraGTx Holdings plc
0.423
0.324 1.30× 30% choppier Biological Products, (No Diagnostic Substances)
ARVN Arvinas, Inc.
0.421
0.300 1.19× 19% choppier Pharmaceutical Preparations
ABUS Arbutus Biopharma Corporation
0.415
0.311 1.02× similar Pharmaceutical Preparations
TRVI Trevi Therapeutics, Inc.
0.414
0.160 1.30× 30% choppier Pharmaceutical Preparations
PRTA Prothena Corporation plc
0.411
0.287 1.04× similar Pharmaceutical Preparations
VERA Vera Therapeutics, Inc.
0.405
0.286 1.29× 29% choppier Pharmaceutical Preparations
REGN Regeneron Pharmaceuticals, Inc.
0.399
0.264 0.73× 27% calmer Pharmaceutical Preparations
RYTM Rhythm Pharmaceuticals, Inc.
0.397
0.291 1.01× similar Pharmaceutical Preparations
IMTX Immatics N.V.
0.395
0.322 1.34× 34% choppier Biological Products, (No Diagnostic Substances)
IMNM Immunome, Inc.
0.394
0.318 1.48× 48% choppier Pharmaceutical Preparations
XNCR Xencor, Inc.
0.390
0.381 1.46× 46% choppier Pharmaceutical Preparations
LGND Ligand Pharmaceuticals Incorporated
0.382
0.232 0.79× 22% calmer Pharmaceutical Preparations
NAMS NewAmsterdam Pharma Company N.V.
0.382
0.208 1.24× 24% choppier Pharmaceutical Preparations

Showing 25 of 30 tickers that qualified. Correlation is of daily returns; 1.000 would mean moving in lockstep, 0.000 no relationship at all.

What this is for

Three questions, one number behind all of them.

How to read the two correlation columns

The one-year figure is what the relationship looks like now. The three-year figure is what it has looked like over a longer stretch. Comparing them is the point: when they agree, the relationship is structural and likely to hold. When the one-year number is far below the three-year one, something has changed — a shift in business mix, an index reconstitution, a sector that has stopped moving together — and the recent figure is the one to trust less, not more.

Correlation measures whether two things move together, not whether they move by the same amount. That is why the volatility column is there. Two tickers can correlate at 0.99 while one swings half again as hard, and swapping one for the other would quietly change how much risk you are carrying.

What was deliberately left out

Ranking purely by correlation produces answers that are mathematically perfect and practically useless. The closest matches to AAPL by raw correlation are leveraged AAPL funds at 0.999 — correct, and not replacements for anything. Four filters run before a ticker is allowed to appear:

Where all of that leaves a ticker with no close match, the page says so. A stock with no substitute is a real and useful finding, and inventing a loose one to fill the table would be worse than an empty answer.

Limits, stated up front

Where the numbers come from

Correlations are computed in-house from a daily price history and rebuilt every night. What gets published is the derived statistic — a correlation coefficient, a volatility ratio, an observation count — and nothing from which a price or return series could be reconstructed. The rest of the Markets section is on the Markets overview, including futures positioning extremes and SEC Form 4 insider transactions.