What Moves Like IONS

Ionis Pharmaceuticals, Inc. Pharmaceutical Preparations · Nasdaq

The tradable tickers whose daily moves track IONS most closely over the past year, filtered to risk comparable with IONS's own.

Closest match

ARWR Arrowhead Pharmaceuticals, Inc. — 0.484 correlation over the past year, and 31% choppier than IONS.

About IONS

Annualised volatility 48.4%
Beta vs SPY 0.35
Market correlation 0.098
Traded per day $148.3M
Rate sensitivity -0.12
Volatility sensitivity -0.21

As filed with the SEC twelve months to 2025-12-31 · balance sheet 2026-03-31

Revenue $943.7M
Operating income -$381.7M
Net income -$381.4M
Diluted EPS $-2.38
Total assets $3.45B
Total liabilities $2.96B
Shareholders' equity $491.4M
Cash & equivalents $173.4M
Shares outstanding 165.9M
251 sessions to 2026-11-09 · IONS volatility 48.4% annualised · $148.3M a day
Ticker 1-year correlation 3-year Volatility vs IONS Risk What it is
ARWR Arrowhead Pharmaceuticals, Inc.
0.484
0.459 1.31× 31% choppier Pharmaceutical Preparations
ABEO Abeona Therapeutics Inc.
0.433
0.233 1.38× 38% choppier Pharmaceutical Preparations
XBI State Street SPDR S&P Biotech ETF
0.419
0.483 0.63× 38% calmer Fund
ACAD ACADIA Pharmaceuticals Inc.
0.399
0.266 0.95× similar Pharmaceutical Preparations
CRSP CRISPR Therapeutics AG
0.392
0.330 1.20× 20% choppier Biological Products, (No Diagnostic Substances)
SBIO ALPS Medical Breakthroughs ETF
0.385
0.439 0.69× 31% calmer Fund
NKTX Nkarta, Inc.
0.379
0.264 1.58× 58% choppier Pharmaceutical Preparations
BEAM Beam Therapeutics Inc.
0.372
0.360 1.49× 49% choppier Biological Products, (No Diagnostic Substances)
IDNA iShares Genomics Immunology and Healthcare ETF
0.360
0.395 0.65× 36% calmer Fund
TARS Tarsus Pharmaceuticals, Inc.
0.346
0.199 0.93× similar Biological Products, (No Diagnostic Substances)
NTLA Intellia Therapeutics, Inc.
0.342
0.280 1.58× 58% choppier In Vitro & In Vivo Diagnostic Substances
ALKS Alkermes plc
0.325
0.238 0.84× 16% calmer Pharmaceutical Preparations
STOK Stoke Therapeutics, Inc.
0.319
0.255 1.12× 12% choppier Pharmaceutical Preparations
MLYS Mineralys Therapeutics, Inc.
0.318
0.404 1.28× 28% choppier Pharmaceutical Preparations
MIRM Mirum Pharmaceuticals, Inc.
0.315
0.247 1.01× similar Pharmaceutical Preparations
PTCT PTC Therapeutics, Inc.
0.314
0.317 0.89× 11% calmer Pharmaceutical Preparations
DSGN Design Therapeutics, Inc.
0.314
0.206 1.46× 46% choppier Pharmaceutical Preparations
DNLI Denali Therapeutics Inc.
0.314
0.325 1.15× 15% choppier Biological Products, (No Diagnostic Substances)
GNOM Global X Genomics & Biotechnology ETF
0.312
0.398 0.73× 27% calmer Fund
SRPT Sarepta Therapeutics, Inc.
0.311
0.246 1.46× 46% choppier Pharmaceutical Preparations
VRTX Vertex Pharmaceuticals Incorporated
0.311
0.234 0.61× 39% calmer Pharmaceutical Preparations
PTGX Protagonist Therapeutics, Inc.
0.307
0.162 0.83× 17% calmer Pharmaceutical Preparations
VERA Vera Therapeutics, Inc.
0.307
0.241 1.23× 23% choppier Pharmaceutical Preparations

Showing 23 of 23 tickers that qualified. Correlation is of daily returns; 1.000 would mean moving in lockstep, 0.000 no relationship at all.

What this is for

Three questions, one number behind all of them.

How to read the two correlation columns

The one-year figure is what the relationship looks like now. The three-year figure is what it has looked like over a longer stretch. Comparing them is the point: when they agree, the relationship is structural and likely to hold. When the one-year number is far below the three-year one, something has changed — a shift in business mix, an index reconstitution, a sector that has stopped moving together — and the recent figure is the one to trust less, not more.

Correlation measures whether two things move together, not whether they move by the same amount. That is why the volatility column is there. Two tickers can correlate at 0.99 while one swings half again as hard, and swapping one for the other would quietly change how much risk you are carrying.

What was deliberately left out

Ranking purely by correlation produces answers that are mathematically perfect and practically useless. The closest matches to AAPL by raw correlation are leveraged AAPL funds at 0.999 — correct, and not replacements for anything. Four filters run before a ticker is allowed to appear:

Where all of that leaves a ticker with no close match, the page says so. A stock with no substitute is a real and useful finding, and inventing a loose one to fill the table would be worse than an empty answer.

Limits, stated up front

Where the numbers come from

Correlations are computed in-house from a daily price history and rebuilt every night. What gets published is the derived statistic — a correlation coefficient, a volatility ratio, an observation count — and nothing from which a price or return series could be reconstructed. The rest of the Markets section is on the Markets overview, including futures positioning extremes and SEC Form 4 insider transactions.