What Moves Like IONS

Ionis Pharmaceuticals, Inc. Pharmaceutical Preparations · Nasdaq

The tradable tickers whose daily moves track IONS most closely over the past year, filtered to risk comparable with IONS's own.

Closest match

XBI State Street SPDR S&P Biotech ETF — 0.490 correlation over the past year, and 30% calmer than IONS.

About IONS

Annualised volatility 39.9%
Beta vs SPY 0.35
Market correlation 0.113
Traded per day $141.0M

As filed with the SEC twelve months to 2025-12-31 · balance sheet 2026-03-31

Revenue $943.7M
Operating income -$381.7M
Net income -$381.4M
Diluted EPS $-2.38
Total assets $3.45B
Total liabilities $2.96B
Shareholders' equity $491.4M
Cash & equivalents $173.4M
Shares outstanding 165.9M
252 sessions to 2026-09-10 · IONS volatility 39.9% annualised · $141.0M a day
Ticker 1-year correlation 3-year Volatility vs IONS Risk What it is
XBI State Street SPDR S&P Biotech ETF
0.490
0.524 0.70× 30% calmer Fund
SBIO ALPS Medical Breakthroughs ETF
0.454
0.476 0.78× 22% calmer Fund
GVA Granite Construction Incorporated
0.410
0.208 0.79× 21% calmer Heavy Construction Other Than Bldg Const - Contractors
TARS Tarsus Pharmaceuticals, Inc.
0.399
0.194 1.17× 17% choppier Biological Products, (No Diagnostic Substances)
ARWR Arrowhead Pharmaceuticals, Inc.
0.380
0.433 1.53× 53% choppier Pharmaceutical Preparations
CRSP CRISPR Therapeutics AG
0.362
0.337 1.50× 50% choppier Biological Products, (No Diagnostic Substances)
ALKS Alkermes plc
0.356
0.252 1.01× similar Pharmaceutical Preparations
PTCT PTC Therapeutics, Inc.
0.346
0.322 1.01× similar Pharmaceutical Preparations
KURA Kura Oncology, Inc.
0.338
0.251 1.52× 52% choppier Pharmaceutical Preparations
BIIB Biogen Inc.
0.334
0.366 0.89× 11% calmer Biological Products, (No Diagnostic Substances)
NBIX Neurocrine Biosciences, Inc.
0.329
0.302 0.83× 17% calmer Biological Products, (No Diagnostic Substances)
DNLI Denali Therapeutics Inc.
0.325
0.337 1.41× 41% choppier Biological Products, (No Diagnostic Substances)
PRTA Prothena Corporation plc
0.323
0.227 1.20× 20% choppier Pharmaceutical Preparations
MIRM Mirum Pharmaceuticals, Inc.
0.321
0.257 1.14× 14% choppier Pharmaceutical Preparations
HALO Halozyme Therapeutics, Inc.
0.315
0.275 0.93× similar Biological Products, (No Diagnostic Substances)
IDYA IDEAYA Biosciences, Inc.
0.315
0.363 1.15× 15% choppier Pharmaceutical Preparations
STOK Stoke Therapeutics, Inc.
0.315
0.269 1.47× 47% choppier Pharmaceutical Preparations
VRTX Vertex Pharmaceuticals Incorporated
0.315
0.233 0.72× 28% calmer Pharmaceutical Preparations
AMGN Amgen Inc.
0.312
0.260 0.74× 26% calmer Biological Products, (No Diagnostic Substances)
ALNY Alnylam Pharmaceuticals, Inc.
0.311
0.389 1.17× 17% choppier Pharmaceutical Preparations
AZN AstraZeneca PLC Ordinary Shares
0.310
0.233 0.71× 29% calmer Pharmaceutical Preparations
MGTX MeiraGTx Holdings plc
0.307
0.254 1.50× 50% choppier Biological Products, (No Diagnostic Substances)
BCYC Bicycle Therapeutics plc
0.304
0.275 1.29× 29% choppier Pharmaceutical Preparations
PCVX Vaxcyte, Inc.
0.303
0.293 1.15× 15% choppier Biological Products, (No Diagnostic Substances)
MRK Merck & Company, Inc. Common Stock (new)
0.301
0.252 0.77× 23% calmer Pharmaceutical Preparations

Showing 25 of 26 tickers that qualified. Correlation is of daily returns; 1.000 would mean moving in lockstep, 0.000 no relationship at all.

What this is for

Three questions, one number behind all of them.

How to read the two correlation columns

The one-year figure is what the relationship looks like now. The three-year figure is what it has looked like over a longer stretch. Comparing them is the point: when they agree, the relationship is structural and likely to hold. When the one-year number is far below the three-year one, something has changed — a shift in business mix, an index reconstitution, a sector that has stopped moving together — and the recent figure is the one to trust less, not more.

Correlation measures whether two things move together, not whether they move by the same amount. That is why the volatility column is there. Two tickers can correlate at 0.99 while one swings half again as hard, and swapping one for the other would quietly change how much risk you are carrying.

What was deliberately left out

Ranking purely by correlation produces answers that are mathematically perfect and practically useless. The closest matches to AAPL by raw correlation are leveraged AAPL funds at 0.999 — correct, and not replacements for anything. Four filters run before a ticker is allowed to appear:

Where all of that leaves a ticker with no close match, the page says so. A stock with no substitute is a real and useful finding, and inventing a loose one to fill the table would be worse than an empty answer.

Limits, stated up front

Where the numbers come from

Correlations are computed in-house from a daily price history and rebuilt every night. What gets published is the derived statistic — a correlation coefficient, a volatility ratio, an observation count — and nothing from which a price or return series could be reconstructed. The rest of the Markets section is on the Markets overview, including futures positioning extremes and SEC Form 4 insider transactions.